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Single-domain antibodies and their utility.

Toya Nath Baral1, Roger MacKenzie1,2, Mehdi Arbabi Ghahroudi1,2,3

  • 1Human Health Therapeutics, Life Sciences Division, National Research Council Canada, Ottawa, Ontario, Canada.

Current Protocols in Immunology
|February 11, 2014
PubMed
Summary

Single-domain antibodies (sdAbs) derived from camelids offer unique advantages for immunobiotherapeutics due to their small size and high stability. This work details protocols for isolating and characterizing sdAbs for diverse therapeutic applications.

Keywords:
VHHantibody fragment libraries dimeric VHHheavy-chain antibodiesmultivalencypentabodiessingle-domain antibody

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