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Related Concept Videos

Antigen Processing Pathways01:31

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MHC molecules are key players in the immune response, enabling T cells to recognize and respond to specific antigens. They are present on the surface of all nucleated cells in the body and are instrumental in presenting antigens to T cells and activating them. T cells recognize the MHC-antigen complex and initiate an immune response. MHC class I and MHC class II are two main types of MHC molecules, each associated with a distinct antigen processing pathway.
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Intraluminal vesicles (ILVs) are small vesicles 50-80 nm in diameter formed during the maturation of early endosomes. A specialized endosome containing numerous ILVs is called a multivesicular body (MVB). ILVs contain internalized molecules such as antigens, nucleic acids, proteins, and metabolites. Some of these molecules are released from the MVBs inside exosomes and are transported to other cells. Other MVBs contain molecules that are retained in the ILVs and are later degraded within the...
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Related Experiment Video

Updated: May 3, 2026

Purification of the Membrane Compartment for Endoplasmic Reticulum-associated Degradation of Exogenous Antigens in Cross-presentation
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Endosomal compartment: Also a dock for MHC class I peptide loading.

Wenbin Ma1, Benoît J Van den Eynde

  • 1Ludwig Institute for Cancer Research, de Duve Institute, WELBIO (Walloon Excellence in Life Sciences and Biotechnology), Université catholique de Louvain, Brussels, Belgium.

European Journal of Immunology
|February 12, 2014
PubMed
Summary

The endosomal compartment is now known to support MHC class I molecule loading, challenging previous assumptions. This finding reveals crosstalk between MHC class I and II pathways, impacting vaccine design for viruses and tumors.

Keywords:
Antigen presentation/processingCD8+ T cellsMHCVaccination

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Area of Science:

  • Immunology
  • Cell Biology
  • Molecular Biology

Background:

  • The endosomal compartment is traditionally viewed as exclusive to MHC class II peptide loading.
  • MHC class I peptide loading is typically associated with the endoplasmic reticulum.

Purpose of the Study:

  • To investigate the role of the endosomal compartment in MHC class I peptide loading.
  • To explore the crosstalk between MHC class II and MHC class I antigen-processing pathways.

Main Methods:

  • Utilized recent immunological studies and a report in the European Journal of Immunology.
  • Focused on analyzing peptide loading mechanisms within the endosomal compartment.

Main Results:

  • Demonstrated that the endosomal compartment efficiently supports MHC class I molecule loading.
  • Identified novel crosstalk between MHC class II and MHC class I antigen-processing pathways.

Conclusions:

  • The endosomal compartment is not solely dedicated to MHC class II.
  • Findings offer new perspectives on antigen processing and may influence vaccine development for viral and tumor targets.