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Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
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Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
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Chromatin Isolation by RNA Purification ChIRP
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Long non-coding RNAs: modulators of nuclear structure and function.

Jan H Bergmann1, David L Spector1

  • 1Cold Spring Harbor Laboratory, One Bungtown Road, Cold Spring Harbor, NY 11724, USA.

Current Opinion in Cell Biology
|February 18, 2014
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Summary
This summary is machine-generated.

Long non-coding RNAs (lncRNAs) are crucial regulators of nuclear processes like chromatin organization and gene expression. This review highlights their molecular functions in fine-tuning the nuclear state.

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Area of Science:

  • Molecular Biology
  • Genetics
  • Cell Biology

Background:

  • Long non-coding RNAs (lncRNAs) are increasingly recognized for their regulatory roles in cellular functions.
  • These molecules are involved in organizing nuclear substructures and modulating chromatin states.
  • lncRNAs interact with effector proteins, influencing their activity and gene expression.

Purpose of the Study:

  • To review recent studies on the molecular functions of lncRNAs.
  • To highlight the role of lncRNAs in regulating and fine-tuning the nuclear state.
  • To provide insights into the structural and dynamic regulation within the nucleus.

Main Methods:

  • Literature review of recent studies.
  • Analysis of molecular mechanisms of lncRNA function.
  • Synthesis of findings on lncRNA-mediated nuclear regulation.

Main Results:

  • lncRNAs play significant roles in nuclear organization and chromatin modification.
  • They act as scaffolds and guides for protein complexes.
  • lncRNAs fine-tune gene expression through diverse mechanisms.

Conclusions:

  • lncRNAs are essential components of the regulatory network within the nucleus.
  • Understanding lncRNA functions is key to deciphering nuclear dynamics.
  • Further research will elucidate the full spectrum of lncRNA activities in cellular regulation.