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Decrease in canine endocardial and epicardial electrogram voltages with exercise: implications for pacemaker sensing.

J T Bricker1, K A Ward, A Zinner

  • 1Lillie Frank Abercrombie Section of Cardiology, Baylor College of Medicine, Houston, Texas.

Pacing and Clinical Electrophysiology : PACE
|April 1, 1988
PubMed
Summary
This summary is machine-generated.

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Exercise can alter pacemaker lead function, particularly atrial sensing. This study found significant voltage decreases in canine pacemaker leads during exercise, highlighting potential sensing issues in patients.

Area of Science:

  • Cardiology
  • Biomedical Engineering
  • Electrophysiology

Background:

  • Pacemaker sensing can be affected by exercise, potentially leading to abnormalities.
  • Understanding voltage changes in implanted leads during physical activity is crucial for patient care.

Purpose of the Study:

  • To evaluate changes in endocardial and epicardial voltages during exercise.
  • To assess canine models with permanent pacing leads similar to those used in humans.

Main Methods:

  • Six canines received transvenous and thoracotomy-implanted bipolar pacing leads.
  • Electrograms were recorded at rest and during a standardized exercise protocol over 4 weeks.
  • Unfiltered electrograms were captured using a photographic recorder.

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Main Results:

  • Atrial endocardial bipolar leads showed a 11% mean voltage decrease during exercise.
  • Ventricular endocardial bipolar leads exhibited an 18% mean voltage decrease.
  • Epicardial leads demonstrated smaller, though variable, voltage changes with exercise.

Conclusions:

  • Exercise significantly decreases voltage amplitudes in permanently implanted pacemaker leads, especially endocardial leads.
  • These findings suggest potential atrial and ventricular sensing abnormalities during physical activity in pacemaker patients.
  • Further research is needed to optimize lead design and pacing algorithms for exercise conditions.