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Elimination of bovine haptoglobin from rat circulation
1Chair of Pharmaceutical Biochemistry, Medical Academy, Wrocław.
Abstract:
The rate of elimination from rat circulation of bovine or rat haptoglobin, of their complexes with homologous haemoglobin, and of preparations deprived of the terminal sialic acid (asialo-haptoglobin), was studied. The rate of elimination was identical for bovine haptoglobin and its complexes with bovine or rat haemoglobin (the half-life time, t1/2, was 10 h). The half-life time of complexes of rat haptoglobin with bovine or rat haemoglobin was about 2 h, and it was much shorter than t1/2 for rat haptoglobin (13 h). The shortest half-life time was observed for bovine and rat asialo-haptoglobin, 35 and 15 min, respectively. The elimination curves showed a biphasic or triphasic character, depending on the rate of elimination.