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Related Concept Videos

Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

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Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
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Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

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Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
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Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

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Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
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Dysrhythmias V: Evaluating Dysrhythmias01:30

Dysrhythmias V: Evaluating Dysrhythmias

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Dysrhythmias, also known as arrhythmias, are disturbances in the heart's rhythm that range from benign to life-threatening. A thorough evaluation is crucial for appropriate management and involves a comprehensive medical history, physical examination, and various diagnostic tests.Medical HistorySymptoms: Collect detailed information on palpitations, dizziness, syncope, chest pain, and fatigue. Note their onset, frequency, and triggers.Previous Cardiac Issues: Document any history of heart...
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Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies01:22

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

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The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
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Pericarditis II: Clinical Features and Diagnostic Tests01:19

Pericarditis II: Clinical Features and Diagnostic Tests

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Pericarditis is distinguished by inflammation of the pericardium, the fibrous sac that encases the heart. It can be acute, lasting less than six weeks, or chronic, persisting for over three months. Understanding its clinical manifestations and diagnostic findings is crucial for timely and effective management.Clinical ManifestationsWhile pericarditis can be asymptomatic, it usually presents with characteristic symptoms such as:Chest Pain: The most characteristic symptom of pericarditis is chest...
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A Sensitive and Specific Quantitation Method for Determination of Serum Cardiac Myosin Binding Protein-C by Electrochemiluminescence Immunoassay
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Pericardial fluid and serum biomarkers equally predict ventricular dysfunction.

Sofia Amjad1, Shahid A Sami, Muhammad Nageeb Basir

  • 1Department of Physiology, Ziauddin University, Karachi, Pakistan.

Asian Cardiovascular & Thoracic Annals
|February 18, 2014
PubMed
Summary

Serum and pericardial fluid levels of amino-terminal pro-B-type natriuretic peptide (NT-proBNP) can detect left ventricular systolic dysfunction. NT-proBNP levels in pericardial fluid were higher, but both serum and fluid showed similar diagnostic value in patients undergoing CABG.

Keywords:
Amino terminal pro-B-type natriureticCABGpericardial fluidventricular dysfunction

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Area of Science:

  • Cardiology
  • Biomarkers
  • Cardiac Surgery

Background:

  • Amino-terminal pro-B-type natriuretic peptide (NT-proBNP) is a cardiac hormone elevated in left ventricular dysfunction.
  • Left ventricular systolic dysfunction (LVSD) significantly impacts cardiac health and patient outcomes.

Purpose of the Study:

  • To compare the diagnostic capabilities of serum and pericardial fluid NT-proBNP levels for detecting LVSD.
  • To assess the correlation of NT-proBNP levels with echocardiographic measures of cardiac function.

Main Methods:

  • Echocardiography assessed left ventricular systolic function in 50 patients before coronary artery bypass grafting (CABG).
  • Serum and pericardial fluid samples were collected during CABG surgery.
  • NT-proBNP levels were quantified using electrochemiluminescence immunoassay, and log values were calculated.

Main Results:

  • Pericardial fluid NT-proBNP levels were significantly higher than serum levels in patients with impaired LVSD.
  • Both serum and pericardial fluid NT-proBNP levels demonstrated significant correlations with ejection fraction and ventricular volumes.
  • Receiver operating characteristic curve analysis indicated similar performance for both sample types in discriminating LVSD.

Conclusions:

  • Serum NT-proBNP levels offer comparable diagnostic value to pericardial fluid NT-proBNP for identifying LVSD in patients undergoing CABG.
  • These findings support the utility of serum NT-proBNP as a practical biomarker for assessing cardiac function in this patient population.