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Related Concept Videos

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The nose is composed of an observable exterior segment (external nose) and an internal segment within the skull known as the nasal cavity (internal nose). The external nose, visible on the face, consists of a framework of bone and hyaline cartilage enveloped in skin and muscle and lined with a mucous membrane. This structure is supported by the frontal bone, nasal bones, and maxillary bone and is supplemented by a cartilaginous framework comprising the septal nasal cartilage, lateral nasal...
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Chronic bronchitis is a key phenotype of chronic obstructive pulmonary disease (COPD), characterized by airway-centered inflammation and mucus overproduction. It develops from long-term exposure to harmful particles or gases, most commonly cigarette smoke, which triggers a persistent inflammatory response.Cellular and Structural ChangesInflammation initially affects the large bronchi and later the smaller airways, with infiltration by immune cells, including neutrophils, macrophages, and...
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Updated: May 3, 2026

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Nasal polyposis: current trends.

Renu Rajguru1

  • 1Institute of Aerospace Medicine, Vimanpura, Near Hal Airport, Bangalore, 560017 Karnataka India.

Indian Journal of Otolaryngology and Head and Neck Surgery : Official Publication of the Association of Otolaryngologists of India
|February 18, 2014
PubMed
Summary

Nasal polyps (NP) are common inflammatory growths affecting 4% of the population. This review explores new treatments targeting underlying mechanisms for better NP control and potential cures.

Keywords:
Nasal polypsNew pharmacological optionsPathophysiologySurgery

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Area of Science:

  • Otolaryngology
  • Immunology
  • Genetics

Background:

  • Nasal polyps (NP) are prevalent inflammatory lesions impacting up to 4% of the population.
  • NP symptoms include nasal obstruction, anosmia, and rhinorrhoea, with unclear underlying mechanisms.
  • Associations with allergy, asthma, infection, fungus, cystic fibrosis, and aspirin sensitivity are noted, alongside genetic factors.

Purpose of the Study:

  • To review current understanding of nasal polyp pathophysiology.
  • To present novel and emerging treatment options for nasal polyps.
  • To explore new pharmacological targets for improved disease control and potential cure.

Main Methods:

  • Literature review of current research on nasal polyp pathogenesis.
  • Analysis of recent advancements in medical and surgical management.
  • Identification of potential therapeutic targets including eosinophilic inflammation, IgE, fungi, and Staphylococcus aureus.

Main Results:

  • Corticosteroids are effective but have limitations for long-term use.
  • Endoscopic sinus surgery is a refined option for refractory cases.
  • Recurrence rates remain significant, especially in severe disease.

Conclusions:

  • Understanding NP pathophysiology is crucial for developing novel pharmacotherapeutic approaches.
  • Newer treatment options offer promise for better disease control.
  • Targeting specific inflammatory pathways and pathogens may lead to more effective therapies.