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Updated: May 2, 2026

Accelerated Type 1 Diabetes Induction in Mice by Adoptive Transfer of Diabetogenic CD4+ T Cells
Published on: May 6, 2013
Circulating CD3+56+ cell subset in pre-diabetes.
M Dworacka1, A Wesołowska1, E Wysocka2
1Department of Pharmacology Poznan University of Medical Sciences, Poznań, Poland.
The study found higher counts of CD3+56+ T cells in pre-diabetes patients, suggesting these cells may be early indicators of dysglycemic disease and atherosclerosis risk. Their activity is linked to carbohydrate metabolism.
Area of Science:
- Immunology
- Endocrinology
- Cardiovascular Research
Background:
- CD3+56+ T cells, including NKT-like and NKT cells, are crucial in early immune responses.
- Their role in atherosclerosis development, particularly in dysglycemic conditions like pre-diabetes and type 2 diabetes, remains largely uninvestigated.
Purpose of the Study:
- To investigate the frequency and activity of CD3+56+ T cells in individuals with pre-diabetes and type 2 diabetes.
- To correlate CD3+56+ cell profiles with metabolic parameters and glycemic control.
Main Methods:
- Analysis of peripheral blood CD3+56+ cell counts, granzyme, perforin, and annexin V expression.
- Measurement of fasting glucose, HbA1c, 1,5-anhydroglucitol, and lipid profiles.
Main Results:
- Significantly higher mean counts of CD3+56+ cells were observed in pre-diabetes patients compared to type 2 diabetes and control groups.
- Pre-diabetic patients showed increased CD3+56+ cells producing granzyme and perforin.
- CD3+56+ cell counts were correlated with metabolic factors such as HbA1c and 1,5-anhydroglucitol.
Conclusions:
- Alterations in CD3+56+ cell counts in pre-diabetes and type 2 diabetes are associated with varying degrees of carbohydrate dysregulation.
- CD3+56+ cells may serve as potential biomarkers for early stages of dysglycemic disease and associated cardiovascular risk.
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