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Circulating P-Selectin and Its Glycoprotein Ligand in Nondiabetic Obstructive Sleep Apnea Patients
H M Winiarska1, S Cofta2, L Bielawska3
1Department of Respiratory Medicine, Allergology and Pulmonary Oncology, Poznan University of Medical Sciences, Poznan, Poland.
Advances in Experimental Medicine and Biology
|March 15, 2020
Summary
Serum levels of platelet P-selectin (P-SEL) and P-selectin glycoprotein ligand 1 (PSGL-1) significantly increase with obstructive sleep apnea (OSA) severity. These adhesion molecules correlate with apnea severity and other health parameters in OSA patients.
Area of Science:
- Cardiovascular Research
- Sleep Medicine
- Immunology
Background:
- Selectins and their ligands are crucial in atherosclerosis.
- Their role in obstructive sleep apnea (OSA) pathogenesis is clinically relevant.
Purpose of the Study:
- To assess serum levels of platelet P-selectin (P-SEL) and P-selectin glycoprotein ligand 1 (PSGL-1) across different OSA stages.
- To investigate the relationship between these adhesion molecules and OSA severity.
Main Methods:
- Nondiabetic patients (aged 32-71) with verified OSA underwent polysomnography.
- OSA stages were stratified by apnea/hypopnea index (AHI): OSA-0 (<5), OSA-1 (5-15), OSA-2 (16-30), OSA-3 (>30).
- Serum P-SEL and PSGL-1 were quantified using ELISA kits.
Main Results:
- P-SEL and PSGL-1 levels significantly increased from OSA-0 to OSA-3.
- Positive correlations were observed between P-SEL and AHI, PSGL-1 and AHI, and P-SEL and PSGL-1 in all OSA patients.
- Adhesion molecules correlated with anthropometric parameters, oxygen saturation, and sleep architecture in the OSA-1 group.
Conclusions:
- Serum P-SEL and PSGL-1 consistently increase in nondiabetic OSA patients.
- The elevation of these adhesion molecules correlates with the progression of OSA severity.
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