Related Experiment Video
Updated: May 2, 2026
08:52
Evaluation of Host-Pathogen Responses and Vaccine Efficacy in Mice
Published on: February 22, 2019
9.8K
Toward a new vaccine for pertussis
John B Robbins1, Rachel Schneerson, Joanna Kubler-Kielb
1National Institute of Child Health and Human Development and National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892.
Summary
A new conjugate vaccine using Bordetella bronchiseptica components shows promise against pertussis. This vaccine induces bactericidal antibodies, potentially improving immunity duration and reducing disease transmission.
Area of Science:
- Immunology
- Vaccinology
- Microbiology
Background:
- Current pertussis vaccines have limitations including short duration of action.
- Existing vaccines fail to induce direct killing of Bordetella pertussis.
Purpose of the Study:
- To develop a novel conjugate vaccine for pertussis.
- To overcome limitations of existing pertussis vaccines.
Main Methods:
- A synthetic scheme was used to prepare a conjugate vaccine.
- The vaccine comprises Bordetella bronchiseptica core oligosaccharide linked to BSA.
- Antibodies were tested for bactericidal activity against B. pertussis in mice.
Main Results:
- Conjugate-induced antibodies demonstrated bactericidal activity against B. pertussis.
- Antibody titers correlated with ELISA values.
- The conjugate vaccine is stable and easy to prepare.
Conclusions:
- The novel conjugate vaccine shows potential to enhance the level and duration of immunity.
- This vaccine may reduce the circulation of B. pertussis.
- Genetically altered pertussis toxoid is planned as the carrier protein.
More Related Videos
Related Concept Videos
01:28Diphtheria
175
Diphtheria is an acute, toxin-mediated infectious disease that primarily affects the upper respiratory tract. It is caused by Corynebacterium diphtheriae, a Gram-positive, pleomorphic rod that lacks spore-forming capability and exhibits a characteristic club-shaped morphology under microscopic examination. While C. diphtheriae can asymptomatically colonize mucosal surfaces, clinical disease manifests only when the bacterial strain is lysogenized by a specific β-corynephage. This phage...
175
01:51Vaccinations
44.1K
Overview
44.1K
01:21Vaccines
98
Vaccines are among the most effective tools in preventive medicine, designed to prepare the immune system to recognize and combat infectious agents. By introducing antigens—substances that the immune system identifies as foreign—vaccines stimulate an adaptive immune response that leads to immunological memory. This immunological memory enables the body to mount a faster and more effective response upon future exposures to the actual pathogen.Vaccines can be categorized based on the...
98
01:30Cancer Vaccines
1.3K
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
1.3K
01:23Vaccine Production
144
Vaccine production involves a sequence of upstream and downstream processes to generate a safe and effective immunological product. It begins with cultivating microorganisms, such as viruses or bacteria, to obtain antigenic material. For viral vaccines, mammalian host cells are grown in bioreactors and subsequently infected with the target virus. The virus replicates within the host cells, which are lysed to release viral particles. This lysate is then clarified through filtration or...
144
01:28Pulmonary Tuberculosis V
1.0K
Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
1.0K