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Related Concept Videos

Pancreas01:19

Pancreas

2.9K
The pancreas, an essential organ in the human body, is a pinkish-gray elongated structure located posterior to the stomach. It extends laterally from the duodenum towards the spleen and is firmly bound to the posterior wall of the abdominal cavity. The organ's surface has a lumpy, lobular texture that gives it a unique appearance.
The broad head of the pancreas lies within the loop formed by the duodenum, while its slender body reaches towards the spleen. The tail of the pancreas is short...
2.9K
Cells and Secretions of the Pancreas01:16

Cells and Secretions of the Pancreas

12.8K
The pancreas, a vital organ within the abdominal cavity, plays dual roles in the digestive and endocrine systems, collaborating with exocrine and endocrine cells to maintain optimal digestion and blood sugar levels.
Exocrine function is carried out by acinar cells, organized into clusters known as acini. These cells contribute to digestion by releasing substantial quantities of enzyme-rich, alkaline digestive juices.
Concurrently, the dispersed clusters of endocrine cells throughout the...
12.8K

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Related Experiment Video

Updated: May 2, 2026

Efficient Generation of Pancreas/Duodenum Homeobox Protein 1+ Posterior Foregut/Pancreatic Progenitors from hPSCs in Adhesion Cultures
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Efficient Generation of Pancreas/Duodenum Homeobox Protein 1+ Posterior Foregut/Pancreatic Progenitors from hPSCs in Adhesion Cultures

Published on: March 27, 2019

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Pancreas development in humans.

Fong Cheng Pan1, Marcela Brissova

  • 1aDepartment of Cell and Developmental Biology and Vanderbilt University Program in Developmental Biology bDivision of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.

Current Opinion in Endocrinology, Diabetes, and Obesity
|February 27, 2014
PubMed
Summary
This summary is machine-generated.

Recent advances in human pancreas development and endocrine cell differentiation are highlighted. Understanding human pancreas development can improve protocols for generating functional insulin-producing cells for diabetes therapy.

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Generation of Scaffold-free, Three-dimensional Insulin Expressing Pancreatoids from Mouse Pancreatic Progenitors In Vitro

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Related Experiment Videos

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A System for ex vivo Culturing of Embryonic Pancreas
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Generation of Scaffold-free, Three-dimensional Insulin Expressing Pancreatoids from Mouse Pancreatic Progenitors In Vitro
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Generation of Scaffold-free, Three-dimensional Insulin Expressing Pancreatoids from Mouse Pancreatic Progenitors In Vitro

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Area of Science:

  • Developmental biology
  • Endocrinology
  • Stem cell biology

Background:

  • Mouse pancreas organogenesis research has informed human embryonic stem cell (hESC) differentiation protocols.
  • Current hESC differentiation protocols yield functional human beta-cells primarily in vivo.

Purpose of the Study:

  • To review recent advances in human pancreas development and endocrine cell differentiation.
  • To explore strategies for improving in vitro generation of functional human beta-cells.

Main Methods:

  • Review of current literature on pancreas development and stem cell differentiation.
  • Analysis of progress and limitations in hESC differentiation protocols.

Main Results:

  • Mouse developmental data has been instrumental in creating hESC differentiation protocols.
  • Despite progress, current protocols have limitations in producing functional human beta-cells in vitro.
  • New markers and reagents offer potential for creating a human pancreas expression map.

Conclusions:

  • Enhanced understanding of human pancreas development is crucial for improving hESC differentiation protocols.
  • Developing better in vitro differentiation protocols can advance beta-cell replacement therapy for diabetes.