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Effect of the Garlic Pill in comparison with Plavix on Platelet Aggregation and Bleeding Time

H Fakhar1, A Hashemi Tayer2

  • 1Department of Nursing, Arak University of Medical Sciences, Arak, Iran.

Iranian Journal of Pediatric Hematology and Oncology
|February 28, 2014
PubMed

Insights

Garlic effectively inhibits platelet aggregation, similar to Plavix, and may reduce cardiovascular disease risk. Higher garlic doses also increased bleeding time in healthy volunteers.

Area of Science:

  • Cardiovascular Research
  • Pharmacology
  • Nutraceuticals

Background:

  • Platelet aggregation is a key factor in cardiovascular diseases.
  • Inhibiting platelet aggregation can lower the risk of coronary thrombosis.
  • Previous research suggests garlic possesses anti-platelet properties.

Purpose of the Study:

  • To compare the anti-platelet effects of garlic with Plavix.
  • To evaluate garlic's impact on platelet aggregation and bleeding time.

Main Methods:

  • A randomized clinical trial involving 36 healthy volunteers.
  • Participants received varying doses of garlic (600, 1200, 2400 mg) or Plavix (75 mg) for three weeks.
  • Platelet aggregation and bleeding time were measured before and after treatment.

Main Results:

  • Garlic at 1200 mg and 2400 mg significantly reduced platelet aggregation induced by ADP and arachidonic acid.
  • The 2400 mg garlic group showed a statistically significant increase in bleeding time.
  • Garlic demonstrated comparable anti-platelet effects to Plavix.

Conclusions:

  • Garlic exhibits significant anti-platelet aggregation properties.
  • Garlic can be recommended as a supplementary treatment to reduce platelet aggregation.
  • Further research may explore garlic's role in managing cardiovascular risk.
Abstract

Keywords:
Bleeding TimeGarlicPlatelet Aggregation

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