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Evaluation of cardiac function in patients with thalassemia intermedia

Nm Nouri1, M Naderi1, S Rajaie2

  • 1Children and Adolescent Hygiene Research Center (CAHRC) & Clinical Research Development Center (CRDC), Ali ebn-e Abitaleb (AS) teaching hospital,Zahedan University of Medical Sciences, Zahedan, Iran.

Iranian Journal of Pediatric Hematology and Oncology
|February 28, 2014
PubMed

Insights

Thalassemia intermedia patients show early cardiac dysfunction, with significant differences in echocardiographic parameters compared to healthy individuals. This highlights the need for proactive cardiac monitoring in this population.

Area of Science:

  • Cardiology
  • Hematology
  • Medical Imaging

Background:

  • Thalassemia intermedia presents with symptoms between carriers and major thalassemia.
  • Cardiac dysfunction from anemia and hemosiderosis is a leading cause of mortality.
  • Early detection of cardiac involvement is crucial for managing thalassemia intermedia.

Purpose of the Study:

  • To evaluate cardiac function in thalassemia intermedia patients using echocardiography.
  • To identify specific echocardiographic markers of cardiac dysfunction in this population.
  • To compare cardiac parameters between thalassemia intermedia patients and a healthy control group.

Main Methods:

  • A case-control study involving 22 thalassemia intermedia patients and 66 healthy controls.
  • Echocardiographic parameters were measured and analyzed.
  • Patients had no clinical signs of cardiac involvement prior to the study.

Main Results:

  • Significant differences were observed in left ventricular myocardial performance index (MPI) and left ventricular mass index (LVMI) between groups (P<0.0001).
  • Several other echocardiographic parameters, including ejection fraction (EF) and fractional shortening (SF), showed significant alterations in thalassemia intermedia patients.
  • Right ventricular MPI and isovolumetric relaxation time (IRT) were also significantly different, indicating widespread cardiac impact.

Conclusions:

  • Thalassemia intermedia patients experience earlier cardiac dysfunction compared to the general population.
  • Echocardiography reveals subclinical cardiac abnormalities in these patients.
  • Findings underscore the importance of regular cardiac assessment in managing thalassemia intermedia.
Abstract

Keywords:
AnemiaHeart failurebeta-Thalassemia

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