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[Formulation of multiparticular drug delivery systems by compressing pellets into tablets]
Zsombor Csobán1, Nikolett Kállai1, Adám Polgár1
1Semmelweis Egyetem, Gyógyszerészi Intézet, 1092 Budapest, Hogyes Endre utca 7-9.
Acta Pharmaceutica Hungarica
|March 1, 2014
Summary
Multiparticulate drug delivery systems offer safer therapy by avoiding stability issues. This study reviews pellet production and how compression affects gastroresistant coated beads
Area of Science:
- Pharmaceutical Technology
- Drug Delivery Systems
Context:
- Multiparticulate systems enhance drug therapy efficiency and safety.
- They mitigate stability and incompatibility challenges common in traditional dosage forms.
Purpose:
- To review multiparticulate pellet production methods.
- To investigate factors influencing tablet quality after compression.
- To analyze the impact of formulation variables on gastroresistant bead dissolution.
Summary:
- This work reviews pellet production for multiparticulate systems.
- It examines how formulation variables like compression pressure and excipient levels affect gastroresistant coated bead quality.
- The study investigates the relationship between these variables and the final dissolution profile.
Impact:
- Provides insights into optimizing multiparticulate tablet manufacturing.
- Aids in developing stable and effective gastroresistant drug delivery systems.
- Contributes to understanding the critical quality attributes of compressed multiparticulate formulations.
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