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Drug discovery through stem cell-based organoid models.

Adrian Ranga¹, Nikolche Gjorevski¹, Matthias P Lutolf¹

¹Laboratory of Stem Cell Bioengineering, Institute of Bioengineering, Ecole Polytechnique Fédérale de Lausanne (EPFL), Switzerland.

Advanced Drug Delivery Reviews

|March 4, 2014

Summary

This summary is machine-generated.

New biomimetic drug screening platforms, including organoid culture systems, offer higher fidelity for testing drug bioactivity and toxicity. This review explores these advanced technologies and their potential to improve drug development pipelines.

Keywords:

3D cell culture Drug discovery High-throughput screening Organoid Stem cell

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Using Human Induced Pluripotent Stem Cell-derived Hepatocyte-like Cells for Drug Discovery

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Published on: May 19, 2018

Area of Science:

Biotechnology
Pharmacology
Drug Discovery

Background:

Drug development is lengthy and expensive, with high failure rates for candidates transitioning from in vitro to in vivo testing.
Current in vitro screening methods often lack the biological complexity to accurately predict in vivo efficacy and toxicity.
There is a critical need for more predictive and biomimetic preclinical testing platforms.

Purpose of the Study:

To review novel drug screening technologies that enhance biomimicry.
To provide an overview of organoid culture systems for drug testing.
To discuss challenges and future directions for implementing advanced screening methods in drug development.

Main Methods:

Literature review of recent advancements in drug screening technologies.
Focus on organoid culture systems and their application in bioactivity and toxicity testing.
Analysis of challenges and opportunities for wider adoption in the pharmaceutical industry.

Main Results:

Emerging drug screening platforms increasingly incorporate biomimetic features.
Organoid culture systems demonstrate potential for high-fidelity preclinical testing.
Significant challenges remain in translating these technologies from research to routine drug development.

Conclusions:

Biomimetic platforms, particularly organoids, represent a promising advancement in drug screening.
Overcoming technical and implementation hurdles is crucial for integrating these technologies into drug development.
These novel approaches could significantly reduce drug development costs and timelines by improving candidate selection.