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Updated: May 2, 2026
10:21
A Coregistered Ultrasound and Photoacoustic Imaging Protocol for the Transvaginal Imaging of Ovarian Lesions
Published on: March 3, 2023
2.6K
Pulmonary sequestration presenting elevated CA19-9 and CA125 with ovarian cysts
Hiroaki Komatsu1, Shinjiro Mizuguchi, Nobuhiro Izumi
1Department of Thoracic Surgery, Osaka City University Hospital, Osaka, Osaka, Japan.
Summary
Elevated tumor markers CA19-9 and CA125 in a woman were linked to an intralobar pulmonary sequestration. Surgical removal of the lung lesion normalized the marker levels, indicating its role in production.
Area of Science:
- Oncology
- Pulmonary Medicine
- Gynecology
Background:
- Elevated cancer antigen 19-9 (CA19-9) and cancer antigen 125 (CA125) necessitate thorough investigation.
- Distinguishing the source of elevated tumor markers is crucial for accurate diagnosis and treatment.
Observation:
- A 41-year-old woman presented with elevated CA19-9 and CA125.
- Imaging revealed an intralobar pulmonary sequestration and bilateral ovarian cysts.
- Ovarian cyst resection did not resolve elevated markers.
Findings:
- Pulmonary sequestration tissue showed positive staining for CA19-9 in epithelial and mucus cells.
- Segmentectomy of the pulmonary sequestration led to normalization of both CA19-9 and CA125 levels.
Implications:
- Intralobar pulmonary sequestration can be an extragonadal source of CA19-9 and CA125 production.
- This case highlights the importance of considering pulmonary lesions in the differential diagnosis of elevated tumor markers.
- Surgical resection of the identified pulmonary lesion can effectively resolve unexplained elevations of these tumor markers.
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