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Rate dependence of ventricular extrasystoles: computer identification and quantitative analysis
C Funck-Brentano1, P Coumel, P Lorente
1Division of Cardiology, Hôpital Lariboisière, Paris, France.
Cardiovascular Research
|February 1, 1988
Summary
A new computer program can identify and quantify the rate dependence of arrhythmias using 24-hour Holter recordings. This analysis reveals heart rate influences ventricular extrasystoles, with identifiable upper and lower cycle length limits observed in patients.
Area of Science:
- Cardiology
- Computational Biology
- Medical Informatics
Background:
- Arrhythmias, specifically ventricular extrasystoles, can be influenced by heart rate.
- Understanding rate dependence is crucial for diagnosing and managing cardiac rhythm disorders.
Purpose of the Study:
- To develop and validate a computer program for identifying and quantifying the rate dependence of arrhythmias.
- To investigate the relationship between heart rate and the occurrence of ventricular extrasystoles in apparently healthy individuals.
Main Methods:
- Utilized a novel computer program to analyze 24-hour Holter recordings.
- Grouped sinus cycles based on subsequent ventricular extrasystoles and analyzed cycle lengths.
- Identified upper and lower cycle length limits beyond which extrasystoles disappeared.
Main Results:
- The computer program successfully identified and quantified rate dependence in ventricular extrasystoles.
- Upper and lower cycle length limits were observed in most patients, varying throughout recordings.
- A significant positive correlation was found between these limits and mean sinus cycle length, suggesting heart rate influence.
Conclusions:
- The developed computer program is effective for identifying and quantifying arrhythmia rate dependence.
- In patients with ventricular extrasystoles, rate-dependent upper and lower cycle length limits exist and are related to heart rate, potentially mediated by the autonomic nervous system.