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Assessing Changes in Volatile General Anesthetic Sensitivity of Mice after Local or Systemic Pharmacological Intervention
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The immune response to anesthesia: part 1.
Stacy L Anderson1, Tanya Duke-Novakovski, Baljit Singh
1Department of Veterinary Biomedical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, SK, Canada.
Veterinary Anaesthesia and Analgesia
|March 5, 2014
Summary
Inhaled anesthetics like isoflurane and sevoflurane may protect organs, especially the lungs. Anesthesia protocols can potentially safeguard organs during mechanical ventilation and systemic injuries.
Area of Science:
- Anesthesiology
- Immunology
- Critical Care Medicine
Background:
- The immune system's response to anesthesia is complex.
- Mechanical ventilation and anesthetic agents can modulate immune function.
- Understanding these interactions is crucial for patient outcomes.
Purpose of the Study:
- To review the immune response to anesthesia.
- To examine the effects of mechanical ventilation, inhaled anesthetics, and injectable anesthetics/sedatives on the immune system.
Main Methods:
- Comprehensive literature search using PubMed and Google Scholar (2012-2013).
- Searched veterinary anesthesia and critical care journals from 2000 onwards.
- Included studies without year or species constraints.
Main Results:
- Volatile anesthetic agents (isoflurane, sevoflurane) show potential organ-protective effects.
- The lung is a key target organ for anesthetic-induced protection.
- Anesthetic protocols may mitigate damage from direct pulmonary insults and systemic conditions.
Conclusions:
- Common volatile anesthetics may offer protective benefits to vital organs.
- Anesthesia can be a tool to protect lungs during mechanical ventilation.
- Potential for anesthetic protocols to manage endotoxemia, sepsis, and ischemia-reperfusion injury.
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