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Updated: Aug 14, 2026
Antibody Binding Specificity for Kappa (Vκ) Light Chain-containing Human (IgM) Antibodies: Polysialic Acid (PSA) Attached to NCAM as a Case Study
Published on: June 29, 2016
Variable-region sequence homologies of human kappa-chains with idiotypic serologic similarities
1Department of Physiological Chemistry, University of Wisconsin-Madison 53706.
Abstract:
An antibody to the V-region of a kappa I light chain has been used to detect other human kappa-chains with similar idiotypic specificities that appear to be related to complementarity-determining regions (CDR). Four such proteins, three of which react with this antibody, have been sequenced. While the proteins show relatively strong sequence similarities in their CDR2 regions, the relatively high degree of homology in a localized segment of the V-region of lambda-chains detected by this method was not observed here.
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