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Updated: May 2, 2026
11:39
The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
Published on: July 11, 2013
38.4K
Biologic therapy in erythrodermic and pustular psoriasis
Journal of Drugs in Dermatology : JDD
|March 6, 2014
Summary
Biologic therapy shows promise for severe psoriasis subtypes like erythrodermic and generalized pustular psoriasis. Further controlled studies are needed to confirm the comparative efficacy and safety of these treatments.
Area of Science:
- Dermatology
- Immunology
- Pharmacology
Background:
- Biologic therapy is established for plaque psoriasis.
- Limited data exists for erythrodermic and generalized pustular psoriasis subtypes.
- Severe psoriasis subtypes require effective treatment options.
Purpose of the Study:
- Review safety and efficacy of biologics for severe psoriasis.
- Identify optimal management strategies for these patients.
- Address data gaps in treating erythrodermic and generalized pustular psoriasis.
Main Methods:
- Conducted a literature search on PubMed for English-language studies.
- Included case reports, case series, and open-label, uncontrolled trials.
- Focused on biologic medication use in erythrodermic or generalized pustular psoriasis.
Main Results:
- Infliximab was the most frequently used biologic.
- Other biologics like etanercept, ustekinumab, adalimumab, and anakinra were also used.
- Most patients showed improvement; serious adverse events occurred in 10-12%.
Conclusions:
- Biologic therapy appears effective for erythrodermic and generalized pustular psoriasis.
- Evidence is currently limited due to study design.
- Larger, controlled studies are necessary to evaluate comparative efficacy and safety.
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