Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Clinical Trials01:16

Clinical Trials

8.5K
Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
8.5K
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches01:23

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

627
Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
627
Clinical Trials: Overview01:11

Clinical Trials: Overview

4.7K
Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
4.7K
Ethics in Research01:56

Ethics in Research

23.7K
Today, scientists agree that good research is ethical in nature and is guided by a basic respect for human dignity and safety. However, this has not always been the case. Modern researchers must demonstrate that the research they perform is ethically sound.
23.7K
Bioavailability Study Design: Healthy Subjects Versus Patients01:15

Bioavailability Study Design: Healthy Subjects Versus Patients

248
Bioavailability studies are essential for evaluating a drug's therapeutic efficacy and understanding its absorption patterns under various physiological conditions. Conducting such studies on target patient populations provides more relevant data by simulating real-world disease states. However, practical challenges often necessitate the use of young, healthy adult volunteers as study subjects.Patients may exhibit altered drug absorption patterns due to the effects of the disease itself,...
248
Obedience01:08

Obedience

26.2K
According to obedience research, we may harm others under the forceful pressures of an authority figure (Milgram, 1974). How about if the inappropriate orders were delivered with less force? The increasing interdependence between nurses and physicians compelled Hofling and his colleagues to explore nurses’ reactions to a potentially harmful medical request made by the perceived authority figure, the doctor (Hofling, Brotzman, Dalrymple, Graves, & Pierce, 1966). In this situation,...
26.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Translation and psychometric properties of the Chinese version of the inventory to measure and assess image disturbance in head and neck cancer (IMAGE-HN).

Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation·2026
Same author

Visual Motion Sensitivity in Vestibular Migraine.

Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·2026
Same author

Personalized risk prediction of financial toxicity in patients with cancer: an interpretable machine learning study.

JNCI cancer spectrum·2026
Same author

Tools for Identifying Social Determinants of Health in Head and Neck Cancer: A Scoping Review.

JAMA otolaryngology-- head & neck surgery·2026
Same author

Recurrence After Subtotal Resection of NF-2-Associated Versus Sporadic Vestibular Schwannomas: A Matched-Cohort Analysis.

Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery·2026
Same author

A Pilot Study of Virtual Reality-Vestibular Physical Therapy for Refractory Dizziness.

Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery·2026

Related Experiment Video

Updated: May 2, 2026

Working with Human Tissues for Translational Cancer Research
07:48

Working with Human Tissues for Translational Cancer Research

Published on: November 26, 2015

9.7K

Practical guide to understanding clinical research compliance.

J Gail Neely1, Randal C Paniello, Evan M Graboyes

  • 1Department of Otolaryngology-Head and Neck Surgery, Washington University School of Medicine, St Louis, Missouri, USA.

Otolaryngology--Head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery
|March 7, 2014
PubMed
Summary

This study offers practical recommendations to minimize noncompliance in clinical research, addressing common errors and human error factors for investigators. It aims to simplify complex regulations for better adherence.

Keywords:
Code of Federal RegulationsFederalwide Assuranceclinical researchhuman research protectioninstitutional review board

More Related Videos

A Novel Method for Involving Women of Color at High Risk for Preterm Birth in Research Priority Setting
14:43

A Novel Method for Involving Women of Color at High Risk for Preterm Birth in Research Priority Setting

Published on: January 12, 2018

14.4K
A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts
07:50

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts

Published on: September 20, 2018

15.8K

Related Experiment Videos

Last Updated: May 2, 2026

Working with Human Tissues for Translational Cancer Research
07:48

Working with Human Tissues for Translational Cancer Research

Published on: November 26, 2015

9.7K
A Novel Method for Involving Women of Color at High Risk for Preterm Birth in Research Priority Setting
14:43

A Novel Method for Involving Women of Color at High Risk for Preterm Birth in Research Priority Setting

Published on: January 12, 2018

14.4K
A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts
07:50

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts

Published on: September 20, 2018

15.8K

Area of Science:

  • Clinical Research Ethics
  • Regulatory Compliance in Research

Background:

  • Noncompliance with federal regulations in clinical research can affect even experienced investigators.
  • Causes include investigator overload, lack of regulatory knowledge, attention to detail deficits, and human error.

Purpose of the Study:

  • To condense complex clinical research conduct details into manageable, easily recalled recommendations.
  • To minimize noncompliance events in clinical research.

Main Methods:

  • Illustrates common noncompliance errors with examples.
  • Presents general and specific concepts and methods to reduce noncompliance.
  • Draws from extensive Institutional Review Board (IRB) experience and consultations with principal investigators and research coordinators.

Main Results:

  • Provides a set of actionable recommendations for clinical research conduct.
  • Highlights key differences between clinical practice and clinical research to prevent errors.

Conclusions:

  • Implementing these recommendations can help investigators improve adherence to federal regulations.
  • Proactive management of common errors and understanding research nuances are key to ethical and compliant clinical research.