Related Experiment Videos
[Enoxacin concentration in human prostatic tissue after 3-day administration]
Hinyokika Kiyo. Acta Urologica Japonica
|July 1, 1988
Summary
Enoxacin effectively penetrates prostatic tissue in patients with benign prostatic hypertrophy. Higher enoxacin concentrations were observed in prostatic tissue and serum after 5.5 hours compared to 17 hours post-administration.
Area of Science:
- Pharmacology
- Urology
Context:
- Benign prostatic hypertrophy (BPH) is a common condition in aging men.
- Effective antibiotic penetration into prostatic tissue is crucial for treating associated infections.
Purpose:
- To evaluate the penetration of enoxacin into prostatic tissue.
- To determine enoxacin concentrations in prostatic tissue and serum at different time points after oral administration.
Summary:
- Thirty-five patients with BPH received oral enoxacin (200 mg TID for 3 days preoperatively).
- Prostatic tissue and serum samples were collected 5.5 hours (Group 2) and 17 hours (Group 1) post-final dose.
- Mean enoxacin concentrations were higher in prostatic tissue (2.51 µg/g) and serum (1.78 µg/ml) at 5.5 hours compared to 17 hours (tissue: 1.87 µg/g; serum: 1.05 µg/ml).
Impact:
- Enoxacin demonstrates significant penetration into prostatic tissue.
- The findings suggest optimal timing for enoxacin administration to achieve maximal therapeutic levels in BPH patients.