Ponatinib-induced neutrophilic panniculitis
May Zhang1, Khaled M Hassan, Amy Musiek
1School of Medicine, Washington University in St. Louis, Saint Louis, MO, USA.
Journal of Cutaneous Pathology
|March 8, 2014
Abstract:
Ponatinib is a bcr-abl tyrosine-kinase inhibitor (TKI) used to treat resistant and refractory chronic myeloid leukemia and Philadelphia chromosome-positive acute lymphoblastic leukemia that express bcr-abl. Neutrophilic panniculitis has been described in rare cases of patients on other TKIs in the same class as ponatinib. We present the first case of neutrophilic panniculitis following treatment with ponatinib and summarize the other cases of panniculitis caused by TKIs.
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