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Aquagenic keratoderma. Two new case reports and a new hypothesis.
Georgi Tchernev1, Kristina Semkova2, José Carlos Cardoso3
1Department of Dermatology and Venerology, Saint Kliment Ohridski University, University Hospital Lozenetz, Bulgaria.
Indian Dermatology Online Journal
|March 12, 2014
Summary
Aquagenic keratoderma, characterized by hand wrinkling after water exposure, can affect males and children. Topical aluminum salts show promise in treatment and may indicate cystic fibrosis in some patients.
Area of Science:
- Dermatology
- Medical Genetics
Background:
- Aquagenic keratoderma (AK) is typically a transient condition.
- It predominantly affects young females, presenting as palmar hyper-wrinkling after water immersion.
Observation:
- Two new cases of aquagenic palmoplantar acrokeratoderma are presented.
- These cases involve a child and a young male, expanding the known demographic for AK.
Findings:
- Topical aluminum salts demonstrated significant clinical improvement in the observed cases.
- Aquagenic palmar keratoderma may serve as an early indicator for cystic fibrosis in adolescents and young adults.
Implications:
- This study broadens the understanding of AK's presentation and affected demographics.
- The findings suggest a potential diagnostic role for AK in identifying cystic fibrosis.
- A novel hypothesis regarding the pathogenesis of aquagenic keratoderma has been developed.
