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Magnetic Resonance Imaging

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Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...

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Real-Time Cardiac Mapping with a Noninvasive Imageless Electrocardiographic Imaging System

Real-Time Cardiac Mapping with a Noninvasive Imageless Electrocardiographic Imaging System

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Myocardial T1 mapping: techniques and potential applications.

Jeremy R Burt¹, Stefan L Zimmerman, Ihab R Kamel

¹From the Russell H. Morgan Department of Radiology and Radiological Sciences (J.R.B., S.L.Z., I.R.K., D.A.B.) and Department of Pathology (M.H.), Johns Hopkins University School of Medicine, Baltimore, Md; and Radiology and Imaging Sciences, Clinical Center, and National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, 10 Center Dr, Room 1C355, Bethesda, MD 20892 (D.A.B.).

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|March 13, 2014

Summary

This summary is machine-generated.

T1 mapping, a cardiac magnetic resonance imaging technique, can noninvasively detect diffuse myocardial fibrosis, a predictor of adverse cardiac outcomes. This method shows promise for managing cardiac diseases.

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Cardiac Magnetic Resonance for the Evaluation of Suspected Cardiac Thrombus: Conventional and Emerging Techniques

Cardiac Magnetic Resonance for the Evaluation of Suspected Cardiac Thrombus: Conventional and Emerging Techniques

Published on: June 11, 2019

Area of Science:

Cardiology
Medical Imaging
Biomedical Engineering

Background:

Myocardial fibrosis is a key factor in cardiac disease progression and patient prognosis.
Current diagnostic methods for myocardial fibrosis have limitations, such as sampling bias in histopathology and signal intensity differences in conventional MRI.
Accurate assessment of diffuse myocardial fibrosis is crucial for patient management.

Purpose of the Study:

To evaluate the potential of T1 mapping, a cardiac magnetic resonance (MR) imaging technique, for noninvasively depicting diffuse myocardial fibrosis.
To assess the correlation of T1 mapping with ex vivo fibrosis content.
To explore the role of T1 mapping in the management of cardiac diseases.

Main Methods:

Utilized T1 mapping sequences with gadolinium-enhanced inversion recovery-prepared imaging.
Calculated myocardial T1 relaxation times using image-based signal intensities.
Compared T1 mapping results with established methods and ex vivo fibrosis content.

Main Results:

Myocardium with diffuse fibrosis demonstrated shorter T1 times compared to normal myocardium due to increased contrast material retention.
T1 mapping showed good correlation with ex vivo fibrosis content.
Early studies suggest T1 mapping can distinguish diffuse myocardial fibrosis from normal myocardium.

Conclusions:

T1 mapping is a promising noninvasive method for direct quantification of diffuse myocardial fibrosis.
Further large multicenter studies are needed to establish its role in prognosis and therapeutic assessment.
T1 mapping may become an important tool in the management of cardiac disease.