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Updated: May 2, 2026

Isolation of Exosomes from the Plasma of HIV-1 Positive Individuals
Published on: January 5, 2016
Association between cellular immune activation, target cell frequency, and risk of human immunodeficiency virus type
Catherine A Blish1, Ozge C Dogan, Walter Jaoko
1Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
Abstract:
We performed a case-control study of women at risk of HIV-1 superinfection to understand the relationship between immune activation and HIV-1 acquisition. An increase in the frequency of HIV-1 target cells, but not in other markers of T cell activation, was associated with a 1.7-fold increase in the odds of superinfection. This suggests that HIV-1 acquisition risk is influenced more by the frequency of target cells than by the generalized level of immune activation.
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