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Updated: May 2, 2026

Preparation of Contiguous Bisaziridines for Regioselective Ring-Opening Reactions
Published on: July 28, 2022
Orthogonal reactivity of acyl azides in C-H activation: dichotomy between C-C and C-N amidations based on catalyst
Kwangmin Shin1, Jaeyune Ryu, Sukbok Chang
1Center for Catalytic Hydrocarbon Functionalization, Institute of Basic Science (IBS) , Daejeon 305-701, Korea.
Abstract:
The dual reactivity of acyl azides was utilized successfully in C-H activation by the choice of catalyst systems: while selective C-C amidation was achieved under thermal Rh catalysis, a Ru catalyst was found to mediate direct C-N amidation also highly selectively. Investigations of the mechanistic dichotomy between two catalytic systems are also presented.
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