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Positron emitting magnetic nanoconstructs for PET/MR imaging.

Santosh Aryal1, Jaehong Key, Cinzia Stigliano

  • 1Department of Translational Imaging, Houston Methodist Research Institute, Houston, TX, 77030, USA.

Small (Weinheim an Der Bergstrasse, Germany)
|March 19, 2014
PubMed
Summary

Researchers developed novel positron-emitting magnetic nanoconstructs (PEMs) for combined PET/MRI imaging of solid tumors. These long-circulating agents show promising tumor accumulation and detailed imaging potential in preclinical models.

Keywords:
PET-MRIhybrid imagingiron oxide nanoparticlesmolecular imagingpolymer-lipid nanoparticles

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Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Medical Imaging

Background:

  • Hybrid PET/MRI offers comprehensive diagnostic information but requires advanced contrast agents.
  • Current multi-modal agents are limited in exploiting the full potential of PET/MRI.

Purpose of the Study:

  • To develop and characterize novel positron-emitting magnetic nanoconstructs (PEMs) for combined PET/MRI.
  • To evaluate PEMs for solid tumor imaging in a preclinical setting.

Main Methods:

  • PEMs synthesized using PLGA, lipids, PEG, and USPIOs, functionalized with DOTA and chelated to 64Cu.
  • Characterization included size, transversal relaxivity (r2), and r2/r1 ratio.
  • In vivo evaluation used a murine xenograft model (MDA-MB-231 breast cancer).

Main Results:

  • PEMs exhibited a diameter of 140 ± 7 nm and high transversal relaxivity (r2 = 265.0 ± 10.0 (mM × s)(-1)).
  • Significant tumor accumulation observed, reaching 3.5 ± 0.25% ID/g at 20 h post-injection.
  • PET/MRI correlation revealed non-uniform intratumoral distribution, with peripheral accumulation.

Conclusions:

  • Developed PEMs are long-circulating and possess high relaxivity, suitable for dual PET/MRI.
  • PEMs demonstrate effective tumor accumulation and potential for multi-scale imaging in a clinical context.