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[Investigation of multyphytoadaptogene anti-radiation efficacy in dogs experiments]
Abstract:
The purpose of the work was to elucidate the radioprotective efficacy of multyphytoadaptogene (MPA) in dogs in various conditions of gamma radiation and MPA application. Dogs were given 15% MPA solution with drinking water in 3,6 ml/kg dose per day 2 weeks before the radiating (preventive application), 2 weeks before and 2 weeks after the radiating (preventive and therapeutic application) as well as 2 weeks after the radiating only (therapeutic application). Animals of control groups received radiation. Dogs were exposed to 3,5 Cy acute radiation and 8,0 Gy prolonged radiation. There were no survived dogs in control groups. At the same time MPA increased dogs survival in preventive, preventive and therapeutic as well as therapeutic applications after 3,5 Gy acute radiation and after 8,0 Gy prolonged radiation. MPA improved the somatic state, interfere with leukocytes amount in blood. The data obtained suggest the radioprotective efficacy of MPA.
Insights
Multiphytoadaptogene (MPA) demonstrated significant radioprotective effects in dogs exposed to gamma radiation. MPA application, whether preventive or therapeutic, enhanced survival rates and improved overall health following acute and prolonged radiation exposure.
Area of Science:
- Radiation biology
- Pharmacology
Context:
- Gamma radiation poses significant health risks.
- Developing effective radioprotective agents is crucial for mitigating radiation damage.
Purpose:
- To evaluate the radioprotective efficacy of multyphytoadaptogene (MPA) in dogs under various gamma radiation conditions and administration timings.
Summary:
- Dogs received MPA preventively, therapeutically, or both, before and after exposure to acute (3.5 Gy) and prolonged (8.0 Gy) gamma radiation.
- Control groups exposed to radiation did not survive.
- MPA administration significantly increased survival rates in all application groups and improved somatic state, including leukocyte levels.
Impact:
- MPA shows promising radioprotective properties.
- This study supports the potential use of MPA as a radioprotective agent in mitigating radiation-induced harm.
