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Updated: Mar 13, 2026
![Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate DMBA-TPA](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F60445.jpg&w=3840&q=50)
Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate DMBA-TPA
Published on: December 19, 2019
Spontaneous Carcinoogenesis: Regulation of Adhesion Disorders and Cancer Prevention
E V Bocharov1, R V Karpova1, V G Kucheryanu2
1N. N. Blokhin Russian Cancer Research Center, Ministry of Health of the Russian Federation, Moscow, Russia.
None:
Using high-cancer CBA mice we showed that regulation of the expression of β2 leukocyte integrins LFA-1 and Mac-1 on peripheral blood cells, serum levels of IL-6 and IL-10, and number of dopaminergic neurons in combination with CD8+ lymphocyte infiltration of the tumor and destruction of tumor nodes after preventive administration of a multiphytoadaptogen during the early ontogeny substantially affects the incidence and size of spontaneous hepatocarcinomas and increases the duration and quality of life.
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