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Diagnostic and Prognostic Significance of RASSF8-AS1 lncRNA Expression in Non-Small Cell Lung Cancer.

O V Kovaleva1, V V Sinyov2, M A Rashidova2

  • 1N. N. Blokhin Russian Cancer Research Center, Ministry of Health of the Russian Federation, Moscow, Russia. ovkovaleva@gmail.com.

Bulletin of Experimental Biology and Medicine
|February 9, 2026
PubMed
Summary

The long non-coding RNA RASSF8-AS1 is downregulated in non-small cell lung cancer (NSCLC). High RASSF8-AS1 expression correlates with reduced survival in lung adenocarcinoma patients, suggesting its prognostic potential.

Keywords:
RASSF8-AS1diagnosticslncRNAnon-small cell lung cancerprognosis

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Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Non-small cell lung cancer (NSCLC) is a leading cause of cancer mortality.
  • Long non-coding RNAs (lncRNAs) are increasingly recognized for their roles in cancer development and progression.
  • The specific role of RASSF8-AS1 in NSCLC remains largely unexplored.

Purpose of the Study:

  • To investigate the clinical significance of the lncRNA RASSF8-AS1 in NSCLC.
  • To evaluate RASSF8-AS1 as a potential diagnostic marker for NSCLC histological subtypes.
  • To assess RASSF8-AS1 as a prognostic biomarker for NSCLC patient outcomes.

Main Methods:

  • Quantitative real-time PCR was used to measure RASSF8-AS1 transcript levels.
  • Expression analysis was performed on 31 paired tumor and adjacent normal lung tissue samples from NSCLC patients.
  • Statistical analyses were conducted to correlate RASSF8-AS1 expression with clinicopathological features and overall survival.

Main Results:

  • RASSF8-AS1 was significantly downregulated in both lung adenocarcinoma and squamous cell carcinoma tissues compared to normal lung tissue (p < 0.01).
  • No significant association was found between RASSF8-AS1 expression and patient age, tumor stage, or differentiation grade.
  • High RASSF8-AS1 expression was significantly correlated with reduced overall survival in lung adenocarcinoma patients (HR = 6.063, p = 0.029).

Conclusions:

  • RASSF8-AS1 downregulation is a common event in NSCLC, suggesting its potential as a diagnostic marker for histological subtypes.
  • RASSF8-AS1 may serve as a prognostic biomarker for improved overall survival in lung adenocarcinoma.
  • RASSF8-AS1 warrants further investigation as a potential therapeutic target and prognostic tool in NSCLC, particularly for personalized treatment strategies.