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Updated: Aug 4, 2026
Identifying Dysregulated Genes Induced by Kaposi's Sarcoma-associated Herpesvirus KSHV
Published on: September 14, 2010
Photodynamic therapy of classic Kaposi's sarcoma with video-fluorescence control
A A Shiryaev1, K T Efendiev2, D O Kornev1
1Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of the Russian Federation, Levshin Institute of Cluster Oncology, University Clinical Hospital No.1 ul. Bolshaya Pirogovskaya 6, Moscow 119435, Russian Federation.
Background:
Kaposi's sarcoma (multiple idiopathic hemorrhagic sarcoma, Kaposi's angiosarcoma) is an angioproliferative neoplasm of endothelial origin associated with human herpes virus 8 (HHV - 8) and human immunodeficiency virus (HIV). The incidence of the classical form of Kaposi's sarcoma (КS) varies significantly in different geographical areas from 0.14/1 million people (both men and women) to 10.5 per 1 million men and 2.7 per 1 million women. The onset of КS is typical at the age of 35-39 in men and 25-39 years in women.
Case Report:
A case of successful treatment of a recurrent non-HIV and non-HHV-8 Kaposi's sarcoma with PDT in a 79-year old man.
Results:
After the recieved photodynamic treatment, complete pathologic response was achieved, i.e., Grade 5 tumor response according to Miller-Payne histological grading system (1999). The overall condition has significantly improved with no clinical tumor signs.
Conclusion:
This report describes a good outcome with PDT in the treatment of Kaposi's sarcoma. The results obtained are initial, but encouraging, demonstrating good tolerance, safety and high efficacy of PDT in classical КS. The successful use of PDT in cutaneous manifestations of HIV-associated KS is also described in literature.
