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Updated: May 2, 2026

Application of Design Aspects in Uniaxial Loading Machine Development
Published on: September 19, 2018
Development of solid-supported Glaser-Hay couplings
Valerie T Tripp1, Jessica S Lampkowski, Ryan Tyler
1Department of Chemistry, College of William & Mary , P.O. Box 8795, Williamsburg, Virginia 23187, United States.
Abstract:
While the Glaser-Hay coupling of terminal alkynes is a useful reaction, several issues associated with chemoselectivity preclude its widespread application in synthetic chemistry. To address these issues, a solid-supported Glaser-Hay methodology was developed to afford only asymmetric diyne products. This methodology was then applied to a series of immobilized alkynes with a diverse set of soluble alkynes to generate an array of heterocoupled products in high yields and purities.
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