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Intracardiac thrombus in children with dilated cardiomyopathy

Ahmet Irdem1, Osman Başpınar2, Mehmet Kervancıoğlu2

  • 1Department of Pediatric Cardiology, Gaziantep University Faculty of Medicine, Gaziantep, Turkey. ahmetirdem81@hotmail.com.

Turk Kardiyoloji Dernegi Arsivi : Turk Kardiyoloji Derneginin Yayin Organidir
|March 20, 2014
PubMed

Insights

Patients with dilated cardiomyopathy and cardiac thrombus face high thromboembolism risk. Antiplatelet therapy may be beneficial, even for those with left ventricular ejection fraction (LVEF) over 30%.

Area of Science:

  • Cardiology
  • Internal Medicine

Background:

  • Patients with dilated cardiomyopathy (DCM) and cardiac thrombus have a significant risk of fatal thromboembolic events.
  • Left ventricular systolic ejection fraction (LVEF) is a key indicator of cardiac function in DCM.

Purpose of the Study:

  • To evaluate the efficacy of antiplatelet therapy in patients with DCM and cardiac thrombus, particularly those with reduced LVEF.
  • To investigate thrombus formation in relation to LVEF in DCM patients.

Main Methods:

  • Retrospective review of 83 DCM patients (June 2004 - December 2011).
  • Analysis of intracardiac thrombus incidence and correlation with LVEF.
  • Assessment of antiplatelet therapy (acetylsalicylic acid) use in patients with LVEF ≤30%.

Main Results:

  • Intracardiac thrombus was detected in 6% of DCM patients.
  • No statistically significant difference in mean LVEF was found between patients with and without thrombus (35.2±2.7% vs. 34.7±11.0%, p=0.910).
  • Patients with LVEF ≤30% were routinely treated with acetylsalicylic acid.

Conclusions:

  • Thrombus development occurred in DCM patients with LVEF >30% even without antiplatelet therapy.
  • Prophylactic antithrombotic/antiplatelet therapy is recommended at diagnosis for DCM patients, including those with LVEF >30%.
Abstract

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