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Updated: May 2, 2026

Identification of Antibacterial Immunity Proteins in Escherichia coli using MALDI-TOF-TOF-MS/MS and Top-Down Proteomic Analysis
Published on: May 23, 2021
Proteome reactivity profiling for the discrimination of pathogenic bacteria
Jun-Seok Lee1, Young-Hwa Yoo, Jihye Kang
1Molecular Recognition Research Center, Korea Institute of Science and Technology (KIST), 39-1 Hawolgok-dong, Seoul, 136-791, Korea. junseoklee@kist.re.kr.
Abstract:
Diverse proteome reactivity profiles were obtained using small-molecule electrophiles. Based on the cross-reactivity profile, each protein generated a unique reactivity fingerprint. Here, we report the first proteome reactivity signature-based discrimination of 11 bacteria. Perfect differentiation of 11 bacteria can be achieved using 2 benzyl-halide probes.
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