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Psoriasis occurring in lamellar ichthyosis: response to Epilyt
H P Baden1, H R Byers, M Goldaber
1Harvard Medical School, Department of Dermatology, Massachusetts General Hospital, Boston 02114.
Cutis
|January 1, 1989
Summary
Psoriasis occurring with lamellar ichthyosis is rare. This case highlights diagnostic features and effective scale management with Epilyt.
Area of Science:
- Dermatology
- Genetics
- Histopathology
Background:
- Lamellar ichthyosis is a rare genetic disorder of keratinization.
- Psoriasis is a chronic inflammatory skin condition.
- Co-occurrence of these conditions presents diagnostic challenges.
Observation:
- A patient with lamellar ichthyosis experienced self-limited episodes of a skin condition.
- Histopathology of an eruptive plaque revealed parakeratosis and reduced granular layer.
- Keratin analysis showed a reduced 67 kDa polypeptide in psoriatic epidermis.
Findings:
- Histopathological findings and keratin analysis supported a diagnosis of psoriasis.
- The patient experienced recurrent, self-limited episodes consistent with psoriasis.
- Epilyt demonstrated efficacy in managing scaling.
Implications:
- This case expands the understanding of psoriasis in rare genodermatoses.
- Early diagnosis of psoriasis in ichthyosis patients is crucial.
- Topical treatments like Epilyt can be beneficial for managing psoriatic scales in this context.