Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

[Amyloid K].

H Hintner¹, H Stössl, R Höpfl

¹Universitätsklinik für Dermatologie und Venerologie Innsbruck.

Der Hautarzt; Zeitschrift Fur Dermatologie, Venerologie, Und Verwandte Gebiete

|July 1, 1988

Summary

This summary is machine-generated.

Localized cutaneous amyloid (amyloid K) deposits are primarily composed of keratin filaments, originating from defective keratinocyte apoptosis. These keratin aggregates form amyloid K through impaired degradation processes.

Related Experiment Videos

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

[Pityriasis amiantacea and folliculitis decalvans : An unusual manifestation associated with antitumor necrosis factor-α therapy].

Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete·2017

Same author

Design and functionalities of the MADOR® software suite for dose-reduction management after DTPA therapy.

Radiation protection dosimetry·2015

Same author

Nail psoriasis masqueraded by secondary infection with Rhodotorula mucilaginosa.

Mycoses·2013

Same author

[Diseases of the oral cavity].

Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete·2012

Same author

Seven novel mutations in the ATP2A2 gene of Austrian patients with Darier's disease.

Archives of dermatological research·2011

Same author

Role of immunofluorescence microscopy in dermatology.

Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia·2011

Same journal

Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete·2022

Same journal

[Viral infections of the skin].

Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete·2022

Same journal

[Viral exanthems in children].

Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete·2022

Same journal

[Erratum to: Digital health applications and data protection].

Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete·2022

Same journal

[Virus-induced exanthems in returning travellers].

Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete·2022

Same journal

[Venous ulcus cruris-Surgical treatment].

Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete·2022

See all related articles

Area of Science:

Dermatology
Biochemistry
Cell Biology

Context:

Localized cutaneous amyloid (amyloid K) is a skin deposit.
Previous studies utilized electron microscopy, histochemistry, and immunology.

Purpose:

To investigate the composition and pathogenesis of amyloid K deposits.

Summary:

Amyloid K deposits are mainly keratin filament material, with amyloid P as a secondary component.
Defective keratinocyte apoptosis is the likely pathogenic mechanism.
Keratinocytes form apoptotic bodies that aggregate in the dermis as keratin (Civatte) bodies.
Impaired degradation of these keratin bodies may lead to amyloid K fibril formation.

Impact:

Provides insight into the molecular basis of amyloid K formation.

Suggests potential therapeutic targets related to keratinocyte apoptosis and degradation pathways.