Design and functionalities of the MADOR® software suite for dose-reduction management after DTPA therapy
B Leprince1, P Fritsch2, P Bérard3
1CEA/DSV/iRCM 18 route du Panorama, BP 6, F-92265 Fontenay-aux-Roses, France bruno.leprince@cea.fr.
Radiation Protection Dosimetry
|May 23, 2015
Summary
A new software suite, MADOR®, aids nuclear industry professionals in managing radionuclide biokinetics and internal dosimetry. It improves worker follow-up and handles specific contaminations, ensuring regulatory compliance and accurate dose assessments.
Area of Science:
- Nuclear Medicine
- Occupational Health
- Radiological Protection
Background:
- Occupational exposure to radionuclides necessitates robust biokinetic modeling and internal dosimetry.
- Existing tools may not adequately address specific contaminants like Plutonium (Pu) and Americium (Am) or the impact of chelation therapy.
Purpose of the Study:
- To introduce the MADOR® software suite for biokinetics and internal dosimetry.
- To describe the functionalities of its first two releases: forensic analysis and DTPA treatment effects.
- To enhance dosimetric follow-up for nuclear industry workers.
Main Methods:
- Development of a software suite using Borland C++ Builder™.
- Implementation of a forensic application (Release 0.0) for calculating derived recording levels for intakes.
- Integration of a Release 1.0 module to model the biokinetics of Pu/Am and assess DTPA treatment benefits.
Main Results:
- The MADOR® suite provides tools for improved dosimetric follow-up and management of internal contaminations.
- Release 0.0 enables rapid interpretation of bioassay measurements and informed medical monitoring decisions.
- Release 1.0 quantifies the impact of DTPA on Pu/Am biokinetics and associated dose reduction.
Conclusions:
- The MADOR® software suite offers valuable computing tools for occupational health practitioners in the nuclear industry.
- It supports compliance with French regulations for worker monitoring.
- Validated results demonstrate the suite's reliability for forensic and therapeutic assessments.
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