Related Experiment Video

Updated: May 2, 2026

Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer
09:08

Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer

Published on: January 12, 2020

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From fly wings to targeted cancer therapies: a centennial for notch signaling

Panagiotis Ntziachristos1, Jing Shan Lim2, Julien Sage2

  • 1Howard Hughes Medical Institute and Department of Pathology, NYU School of Medicine, New York, NY 10016, USA; NYU Cancer Institute and Helen L. and Martin S. Kimmel Center for Stem Cell Biology, NYU School of Medicine, New York, NY 10016, USA.

Cancer Cell
|March 22, 2014
PubMed

Insights

Notch signaling regulates cell fate but can also drive or suppress tumors. This review explores Notch

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Cancer Research

Background:

  • Notch signaling is a conserved pathway regulating cell-fate decisions.
  • Aberrant Notch pathway activity is implicated in various cancers.

Purpose of the Study:

  • To review the dual roles of Notch signaling in tumorigenesis.
  • To elucidate molecular mechanisms of Notch in cancer.
  • To discuss therapeutic strategies targeting Notch in human cancers.

Main Methods:

  • Literature review of Notch signaling in cancer.
  • Analysis of molecular mechanisms in hematopoietic and solid tumors.

Main Results:

  • Notch signaling exhibits both protumorigenic and tumor-suppressive functions.
  • Specific molecular pathways mediate these opposing roles in different cancer types.

Conclusions:

  • Understanding Notch's complex roles is crucial for cancer therapy.
  • Targeting the Notch pathway offers potential therapeutic strategies for human cancers.

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