Related Experiment Video

Updated: May 1, 2026

Invasive Hemodynamic Monitoring of Aortic and Pulmonary Artery Hemodynamics in a Large Animal Model of ARDS
08:12

Invasive Hemodynamic Monitoring of Aortic and Pulmonary Artery Hemodynamics in a Large Animal Model of ARDS

Published on: November 26, 2018

10.0K

Arterial hypertension in patients with heart failure

Javier Díez1

  • 1Department of Cardiovascular Sciences, Centre of Applied Medical Research, Pamplona, Spain; Department of Cardiology and Cardiac Surgery, University Clinic, Pamplona, Spain; University of Navarra, Pamplona, Spain.

Heart Failure Clinics
|March 25, 2014
PubMed

Insights

Hypertensive heart disease involves more than just adaptive changes; it includes pathological remodeling of the heart. Early detection of heart failure risk in hypertension patients is now possible.

Area of Science:

  • Cardiology
  • Hypertension Research
  • Pathology

Background:

  • Hypertensive heart disease (HHD) was traditionally viewed as left ventricular wall adaptive hypertrophy due to elevated blood pressure.
  • Emerging evidence suggests HHD also involves pathological structural remodeling of the myocardium.

Purpose of the Study:

  • To challenge the traditional paradigm of HHD.
  • To highlight the role of pathological remodeling in HHD.
  • To explore early detection of heart failure risk in hypertensive patients.

Main Methods:

  • Review of recent findings in hypertensive animals and patients.
  • Analysis of hemodynamic and nonhemodynamic factors in arterial hypertension.
  • Investigation of early detection methods for heart failure predisposition.

Main Results:

  • Hypertensive heart disease (HHD) involves pathological myocardial remodeling beyond adaptive hypertrophy.
  • Altered hemodynamic and nonhemodynamic factors in hypertension contribute to HHD.
  • Potential for detecting heart failure predisposition before clinical symptoms.

Conclusions:

  • HHD is a complex condition involving pathological remodeling.
  • Early detection of heart failure risk in hypertensive individuals is feasible.
  • This approach offers new avenues for preventing major arterial complications.

Keywords:
Arterial hypertensionEjection fractionHeart failureLeft ventricular hypertrophyMyocardial remodeling

More Related Videos

Left Atrial Stenosis Induced Pulmonary Venous Arterialization and Group 2 Pulmonary Hypertension in Rat08:34

Left Atrial Stenosis Induced Pulmonary Venous Arterialization and Group 2 Pulmonary Hypertension in Rat

Published on: November 18, 2018

6.9K
Author Spotlight: Development of a Minimally Invasive Large-Animal Model for Reliable and Reproducible Cardiovascular Research06:51

Author Spotlight: Development of a Minimally Invasive Large-Animal Model for Reliable and Reproducible Cardiovascular Research

Published on: October 20, 2023

1.8K

Related Concept Videos

Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
1.9K
Heart Failure III: Clinical Manifestations01:26

Heart Failure III: Clinical Manifestations

Heart failure (HF) manifests primarily as dyspnea, fatigue, and fluid retention, resulting in peripheral and pulmonary edema. Symptoms may vary depending on which ventricle is more affected, left or right.Left-Sided Heart FailureAlso known as left ventricular failure, this condition results from the left ventricle's inability to fill or eject sufficient blood into the systemic circulation. It leads to pulmonary congestion, which occurs when the left ventricle fails to eject blood effectively...
1.2K
Heart Failure I: Introduction01:27

Heart Failure I: Introduction

Heart failure refers to a clinical syndrome caused by structural or functional cardiac disorders that prevent the heart from pumping an adequate amount of blood to meet the body's metabolic needs. This condition often arises from myocardial infarction or ischemia, leading to decreased cardiac output, reduced tissue perfusion, impaired gas exchange, fluid volume imbalance, and decreased functional ability.Heart failure can result from disruptions in the mechanisms that regulate cardiac output...
1.7K
Heart Failure Drugs: Inhibitors of Renin-Angiotensin System01:26

Heart Failure Drugs: Inhibitors of Renin-Angiotensin System

The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...
1.9K
Pathophysiology of Heart Failure01:17

Pathophysiology of Heart Failure

Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
4.8K
Heart Failure VII: Nursing Interventions01:30

Heart Failure VII: Nursing Interventions

The first step in nursing management of a patient with heart failure involves thoroughly assessing the patient's medical history.Subjective Data: Obtain the patient's medical history of coronary artery disease, hypertension, myocardial infarction, and symptoms like dyspnea, orthopnea, and paroxysmal nocturnal dyspnea.Objective Data: Conduct a physical examination to identify findings such as jugular vein distention, pulmonary crackles, tachycardia, murmurs, peripheral edema, and vital signs,...
787