High-performance thin layer chromatography to assess pharmaceutical product quality

Area of Science:

• Analytical Chemistry
• Pharmaceutical Sciences

Background:

• Quality control is crucial for pharmaceutical products.
• Traditional methods may have limitations in sustainability and cost-effectiveness.

Purpose of the Study:

• To evaluate the sustainability, robustness, and economic benefits of High-Performance Thin-Layer Chromatography (HPTLC).
• To assess HPTLC's suitability for pharmaceutical quality control.

Main Methods:

• A comparative study was conducted across three laboratories.
• Three batches of cotrimoxazole tablets were analyzed using different quantification techniques.

Main Results:

• The average relative standard deviation for the assay across the three lots was 1.2.
• The range of relative standard deviation was 0.65-2.0, indicating consistent results.

Conclusions:

• HPTLC analysis provides valid results suitable for pharmaceutical product quality assessment.
• The study indicates that local pharmaceutical manufacturers can achieve high-quality production using HPTLC.