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Related Experiment Videos

[In Process Citation].

Nicole Nigro1, Mirjam Christ-Crain1, Christian Meier1

  • 1Klinik für Endokrinologie, Diabetologie und Metabolismus, Universitätsspital Basel.

Therapeutische Umschau. Revue Therapeutique
|March 28, 2014
PubMed
Summary
This summary is machine-generated.

Late onset hypogonadism in aging males involves sexual symptoms and low testosterone. Testosterone replacement therapy offers benefits but requires careful consideration due to limited long-term safety and efficacy data.

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Area of Science:

  • Endocrinology
  • Andrology
  • Geriatrics

Context:

  • Late onset hypogonadism (LOH) definition is debated, involving sexual symptoms and low testosterone levels (< 8-11 nmol/l).
  • Testosterone replacement therapy (TRT) prescriptions for aging males have surged over 170% in 5 years.
  • Epidemiological data suggest inverse links between testosterone and obesity, insulin resistance, metabolic syndrome, and type 2 diabetes.

Purpose:

  • To review the current understanding of LOH and TRT in aging males.
  • To evaluate the known benefits and conflicting effects of TRT on body composition, bone density, sexual function, and mood.
  • To assess the controversial evidence regarding TRT's impact on insulin resistance, HbA1c, prostate health, and cardiovascular events.

Summary:

  • TRT may improve muscle mass, fat mass, and bone mineral density in aging males.
  • Conflicting evidence exists regarding TRT's effects on muscle strength, sexual function, mood, and quality of life.
  • Long-term safety and efficacy of TRT remain unestablished, with potential concerns for prostate and cardiovascular events, necessitating cautious application and further research.

Impact:

  • Highlights the need for carefully designed placebo-controlled trials to establish TRT's long-term risks and benefits in aging men.
  • Emphasizes that TRT should be reserved for aging men with confirmed hypogonadism and clinical symptoms, with thorough risk-benefit assessment.
  • Underscores the necessity of vigilant monitoring for potential side effects during TRT.