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State-dependent blocker interactions with the CFTR chloride channel: implications for gating the pore

Paul Linsdell1

  • 1Department of Physiology and Biophysics, Dalhousie University, PO Box 15000, Halifax, NS, B3H 4R2, Canada, paul.linsdell@dal.ca.

Pflugers Archiv : European Journal of Physiology
|March 28, 2014
PubMed
Summary

Tetracyanoplatinate (Pt(NO2)4(2-)) ions block cystic fibrosis transmembrane conductance regulator (CFTR) channels, reducing chloride flow and altering channel gating. This suggests Pt(NO2)4(2-) interacts with a single site within the CFTR pore.

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