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Related Experiment Videos

von Willebrand factor is an acute phase reactant in man.

B E Pottinger1, R C Read, E M Paleolog

  • 1Section of Vascular Biology, MRC Clinical Research Centre, Harrow, U.K.

Thrombosis Research
|February 15, 1989
PubMed
Summary

Plasma von Willebrand factor antigen (vWfAg) levels significantly increase during acute infections. These elevations in vWfAg correlate with C-reactive protein (CRP) and normalize as infections resolve, indicating vWf is an acute phase reactant.

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Area of Science:

  • Infectious Diseases
  • Hematology
  • Immunology

Background:

  • Von Willebrand factor (vWf) is crucial for hemostasis.
  • Acute phase reactants are proteins whose plasma concentrations increase or decrease in response to inflammation.

Purpose of the Study:

  • To investigate whether von Willebrand factor antigen (vWfAg) functions as an acute phase reactant in humans.

Main Methods:

  • Measured plasma vWfAg concentrations in patients with acute infectious illnesses.
  • Correlated vWfAg levels with serum C-reactive protein (CRP) levels.
  • Monitored vWfAg and CRP levels longitudinally during infection and recovery.

Main Results:

  • vWfAg concentrations were significantly elevated (mean >3-fold above normal) in patients with bacterial, viral, or parasitic infections.

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  • Elevated vWfAg levels strongly correlated with elevated CRP levels in individual patients.
  • vWfAg and CRP concentrations returned to normal within 3-4 weeks post-infection in longitudinal studies.

    • Conclusions:

    • Von Willebrand factor (vWf) demonstrates characteristics of an acute phase reactant in humans.
    • vWfAg levels increase during acute inflammatory conditions associated with infection.
    • vWf may play a role in the host's response to infection.