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Updated: May 1, 2026

Online Transcranial Magnetic Stimulation Protocol for Measuring Cortical Physiology Associated with Response Inhibition

Online Transcranial Magnetic Stimulation Protocol for Measuring Cortical Physiology Associated with Response Inhibition

Published on: February 8, 2018

Cortical dopamine release during a behavioral response inhibition task.

Daniel S Albrecht¹, David A Kareken, Bradley T Christian

¹Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, Indiana, 46202; Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, Indiana, 46202.

Synapse (New York, N.Y.)

|March 29, 2014

Summary

This summary is machine-generated.

This study shows dopamine release in brain regions controlling impulsive behavior during a stop signal task. This demonstrates dopamine

Keywords:

D2 receptor dopamine fallypride impulsivity positron emission tomography stop signal task

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Last Updated: May 1, 2026

Online Transcranial Magnetic Stimulation Protocol for Measuring Cortical Physiology Associated with Response Inhibition

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Published on: February 8, 2018

Intracortical Inhibition Within the Primary Motor Cortex Can Be Modulated by Changing the Focus of Attention

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Published on: September 11, 2017

Correlating Behavioral Responses to fMRI Signals from Human Prefrontal Cortex: Examining Cognitive Processes Using Task Analysis

Correlating Behavioral Responses to fMRI Signals from Human Prefrontal Cortex: Examining Cognitive Processes Using Task Analysis

Published on: June 20, 2012

Area of Science:

Neuroscience
Radiochemistry
Psychiatry

Background:

Dopamine (DA) dysregulation in fronto-striatal circuits is linked to impulsivity in substance use disorders.
Previous research has not directly measured DA release during tasks requiring impulse control.

Purpose of the Study:

To determine if a response inhibition task (stop signal task; SST) elicits detectable extrastriatal dopamine release in healthy individuals.
To investigate dopamine release in brain regions associated with inhibitory control.

Main Methods:

Positron Emission Tomography (PET) imaging using [(18)F]Fallypride (FAL) was performed on nine healthy males.
Participants underwent FAL PET scans during both an SST and a baseline 'Go' task on separate days.
Voxel-wise analysis of parametric BPND images was conducted using SPM8.

Main Results:

Significant SST-induced dopamine release was observed in cortical regions crucial for inhibitory control, including the insula, cingulate cortex, orbitofrontal cortex, precuneus, and supplementary motor area.
A positive correlation was found between stop signal reaction time and dopamine release in the left orbitofrontal cortex, right middle frontal gyrus, and right precentral gyrus.

Conclusions:

Positron Emission Tomography (PET) with [(18)F]Fallypride (FAL) is a feasible method for studying dopamine release during response inhibition.
These findings enable future investigations into the relationship between dopamine function and impulsive behaviors.