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Updated: May 1, 2026

Preparation and In Vivo Use of an Activity-based Probe for N-acylethanolamine Acid Amidase
Published on: November 23, 2016
Synthesis, antibiotic activity and structure-activity relationship study of some 3-enaminetetramic acids
Yong-Chul Jeong1, Muhammad Anwar1, Mark G Moloney1
1Chemistry Research Laboratory, University of Oxford, Mansfield Rd, Oxford OX1 3TA, UK.
Abstract:
The synthesis and evaluation of 3-enaminetetramic acids as antibacterial agents is reported; contrary to the analogous 3-acyltetramic acids, the enaminetetramic acid class of compound exhibits modest antibacterial activity against a limited spectrum of organisms, and even that activity is strongly dependent on the identity of the tetramate ring substituents. Moreover, these compounds appear to have a different mode of action to the analogous 3-acyltetramic acids, and appear to offer more limited opportunity for further elaboration in drug discovery.
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