Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hepatocellular membrane function during chronic burn injury.

J P Minei1, Y Fong, M A Marano

  • 1Department of Surgery, New York Hospital- Cornell Medical Center, New York 10021.

The Journal of Surgical Research
|April 1, 1989
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Coherent beam transformations using multimode waveguides.

Optics express·2010
Same author

Changes in respiratory efficiency and dynamics in experimental pulmonary congestion.

The American journal of medicine·2010
Same author

Preparation of simple and dried smallpox vaccine in gum acacia; a preliminary report.

Chinese medical journal (Peking, China : 1932)·2010
Same author

Experimental infection of silkworm pupa with typhus rickettsia: a preliminary report.

Chinese medical journal (Peking, China : 1932)·2010
Same author

Changes in the efficiency and dynamics of respiration in experimental congestion of the lungs.

The Journal of clinical investigation·2010
Same author

Paroxysmal kinesigenic choreoathetosis: evidence of linkage to the pericentromeric region of chromosome 16 in four Chinese families.

European journal of neurology·2010
Same journal

Emergency Surgical Cricothyrotomy Videos Online: Reliability and Training Quality Evaluation.

The Journal of surgical research·2026
Same journal

Management of Concomitant Traumatic Abdominal Vascular and Gastrointestinal Injuries: A Descriptive Study.

The Journal of surgical research·2026
Same journal

Article Processing Charges in General Surgery Journals: Implications for Equitable Publishing Access in Low-Income and Middle-Income Countries.

The Journal of surgical research·2026
Same journal

Association of Distal Internal Carotid Artery Tortuosity With Carotid Artery Stenting Outcomes.

The Journal of surgical research·2026
Same journal

Appendectomy and Subsequent Type 2 Diabetes - A National Cohort study.

The Journal of surgical research·2026
Same journal

Perceptions and Barriers to Intraoperative Non-technical Skills Feedback in General Surgery: A Mixed-Methods Study.

The Journal of surgical research·2026
See all related articles

Hepatocellular membrane dysfunction, indicated by depolarization, occurs after injury. This study shows burn and infection in rats leads to hepatic membrane hyperpolarization, maintaining liver function during critical illness.

Area of Science:

  • Physiology
  • Hepatology
  • Burn Medicine

Background:

  • Hepatocellular membrane dysfunction (depolarization) is linked to acute injury and bacteremia.
  • The role of hepatocellular membrane potential during combined thermal injury and infection is not well understood.

Purpose of the Study:

  • To investigate hepatocellular membrane potential changes in rats with concurrent burn injury and Pseudomonas aeruginosa infection.
  • To determine if hepatic membrane dysfunction occurs in the setting of ongoing thermal injury and infection.

Main Methods:

  • Wistar rats were subjected to sham burn, burn, or burn with infection (Pseudomonas aeruginosa).
  • Hepatocellular transmembrane potentials, body and liver weights, and hepatic ATP, RNA, DNA, and protein contents were measured on days 3 and 7 post-injury.

Related Experiment Videos

  • Corticosterone levels were also assessed.

    • Main Results:

    • By day 7, burn/infected rats showed conserved hepatic mass despite significant weight loss.
    • Hepatic transmembrane potential hyperpolarized significantly in burn/infected rats compared to controls.
    • Burn/infected rats exhibited increased hepatic RNA and DNA content, with elevated corticosterone levels.

    Conclusions:

    • Hepatic membrane hyperpolarization and increased RNA content were observed in rats with combined burn and infection.
    • These changes were specific to the combined insult and not solely due to burn or starvation.
    • Hepatic membrane hyperpolarization may be a mechanism for maintaining liver function during severe burn infections.