Related Experiment Video
Updated: May 1, 2026

Isolation of Mesenchymal Stem Cells from Human Alveolar Periosteum and Effects of Vitamin D on Osteogenic Activity of Periosteum-derived Cells
Published on: May 4, 2018
[Bone and Stem Cells. Regulatory mechanism of mesenchymal stem cell differentiation to osteoblasts]
Itsuro Endo1, Toshio Mastumoto
1Department of Medicine and Bioregulatory Sciences, The University of Tokushima Graduate School of Medical Sciences, Japan.
Abstract:
Differentiation of mesenchymal stem cells to osteoblastic lineage cells is regulated positively by factors such as mechanical strain and parathyroid hormone, and is negatively regulated by factors including aging and glucocorticoids. Wnt/β-catenin pathway plays an important role in controlling the bifurcation of mesenchymal stem cell differentiation between osteoblastic and adipocytic lineages. In this review, we overview the outline of the mechanism of action as well as interrelation of the actions of these factors in controlling osteoblast differentiation, with special reference to the role of interleukin-11 in these processes.
Related Concept Videos
Bone Cells and Tissue
Osteoblasts and Osteocytes
The osteoblast is the bone cell responsible for forming new bone tissue. It is found in the growing portions of bone, including the...
Mesenchymal Stem Cells
Stem Cell Niche
Bone Remodeling
Osteoclasts in Bone Remodeling
Master Transcription Regulators

