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Triple infection keratitis.

Manotosh Ray¹, Lim Chen Siang Nigel, Anna Marie Tan

¹Department of Ophthalmology (M.R., A.M.T.), National University Health System, Singapore, Singapore; and Yong Loo Lin School of Medicine (M.R., L.C.S.N., A.M.T.), National University of Singapore, National University Health System, Singapore, Singapore.

Eye & Contact Lens

|April 1, 2014

Summary

This summary is machine-generated.

Triple infection keratitis, often linked to topical steroid use, presents with large corneal infiltrates and hypopyon. Fungal isolates are common, requiring a high suspicion for polymicrobial causes.

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Area of Science:

Ophthalmology
Infectious Diseases
Microbiology

Background:

Triple infection keratitis is a severe form of microbial keratitis.
Polymicrobial infections of the cornea pose diagnostic and therapeutic challenges.

Purpose of the Study:

To analyze the demographics, risk factors, and clinical and microbiological characteristics of triple infection keratitis.
To identify typical features and outcomes of triple infection keratitis.

Main Methods:

Retrospective case series of five patients with culture-positive triple infection keratitis.
Analysis of demographics, risk factors, clinical presentation, microbiological data, and treatment outcomes.

Main Results:

Topical steroid use was the most frequent risk factor (80%).
All cases presented with hypopyon and had at least one fungal isolate.
Common pathogens included Pseudomonas aeruginosa and Candida albicans.

Conclusions:

Triple infection keratitis often involves multiple risk factors and fungal co-infection.
Features include large infiltrates, hypopyon, and a prolonged disease course.
Prompt recognition and management are crucial to prevent severe outcomes like panophthalmitis.