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Updated: May 1, 2026

The Establishment of a Murine Mandibular Molar Extraction Socket Healing Model
Published on: January 13, 2023
Buccal bone deficiency in fresh extraction sockets: a prospective single cohort study
Antonio Barone1, Massimiliano Ricci2, Georgios E Romanos3
1Department of Surgical, Medical, Molecular and Critical Area Pathology, University of Pisa, Pisa, Italy.
Xenograft and platelet-rich fibrin (PRF) effectively repaired buccal bone defects in fresh extraction sockets, improving soft tissue and keratinized gingiva width for dental implant placement.
Area of Science:
- Dental Implantology
- Periodontology
- Regenerative Dentistry
Background:
- Buccal bone defects in fresh extraction sockets compromise esthetic zone implant placement.
- Ridge preservation techniques are crucial for maintaining alveolar bone height and width.
Purpose of the Study:
- To evaluate xenograft and collagen membranes for treating buccal bone defects in fresh extraction sockets.
- To assess the efficacy of these materials in the esthetic zone prior to implant placement.
Main Methods:
- Prospective single cohort study of 33 patients with buccal bone plate deficiency (>2 mm).
- Treatment involved corticocancellous porcine bone and platelet-rich fibrin (PRF) with a collagen membrane.
- Secondary soft tissue healing was allowed with exposed membranes.
Main Results:
- All sites facilitated implant placement.
- Significant increase in keratinized mucosa width (2.3 mm at 5 months, 3.2 mm at 1 year).
- Improved facial soft tissue levels and bone levels (0.8 mm mesial, 0.7 mm distal).
Conclusions:
- Xenograft and PRF are effective for ridge preservation in extraction sockets with buccal bone dehiscence.
- Secondary healing did not impede bone formation; soft tissue and gingival width improved.
- The technique supports successful implant placement in the esthetic zone.
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